Amoxicillin, Amoxicillin/Clavulanate for UTIs (Uncomplicated)
Based on "Principles and Practice of Infectious Diseases"
written by John E. Bennett, MD
Most Urinary Tract Infections (UTIs) represent acute uncomplicated cystitis (bladder infection).
- Amoxicillin/clavulanate is now regarded as a third-line treatment for UTI in preference to amoxicillin alone 1.
- Amoxicillin/clavulanate is an appropriate choice for bladder infection when other recommended antibiotics cannot be used.
- Good choice for bladder infections during pregnancy2.
- Amoxicillin-clavulanate is less effective than ciprofloxacin or levofloxacin.
Amoxicillin/clavulanate dosage for UTI:
500/125 mg twice per day for 7 days.
875/125 mg twice per day for 7 days.
According to the latest Guidelines amoxicillin is no longer recommended for urinary tract infections because of resistance and higher recurrence rates1.
- Amoxicillin is FDA approved for UTIs.
- Currently amoxicillin is not suitable as empiric therapy for cystitis but can be prescribed if urine culture shows susceptibility.
- Amoxicillin reaches high urinary concentrations.
- Safe to use during pregnancy.
- Most E. coli are now resistant to amoxicillin, so it is not good for empirical treatment.
- Amoxicillin has a relatively poor efficacy.
- Patients are more likely to developed recurrent infection after amoxicillin therapy than after first line medications.
- Amoxicillin should NOT be used for UTIs in men because of great likelihood of deep tissue infection of the kidney or prostate.
Amoxicillin dosage for UTI: 250-500 mg 4 times daily for 7 days3.
Can Amoxicillin Treat UTI?Yes, amoxicillin can treat bladder infection caused by susceptible bacteria. So, your doctor can prescribe amoxicillin if this antibiotic is appropriate in your case.
Is Amoxicillin a Good Choice for UTI?
Amoxicillin alone is not considered to be an effective treatment for UTI in the U.S. because of high resistance rates. Amoxicillin/clavulanate (Augmentin®) is more effective.
How Fast Does Amoxicillin Work?
The recommended duration of treatment is 7 days. You may notice improvement in symptoms in three days.
- 1. Gupta K, Hooton TM, Naber KG, et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis. 2011;52(5):e103–e120.
- 2. Delzell JE Jr, Lefevre ML. Urinary tract infections during pregnancy. Am Fam Physician. 2000 Feb 1;61(3):713-21. Available at American Academy of Family Physicians
- 3. Amoxil® Prescribing Information PDF
Published: August 01, 2018 by eMedExpert staff
Last updated: February 20, 2019