List of Pregnancy Category X Medications

by eMedExpert staff

Pregnancy category X

Pregnancy Category X drugs are contraindicated in women who are or may become pregnant. For medications assigned this category there are studies, adequate well-controlled or observational, in animals or pregnant women that have demonstrated positive evidence of fetal abnormalities.

The below list represents information on select medications that are classified as Pregnancy Category X (clearly teratogenic) medications. The listing is not inclusive, it may not cover all available medications on the world market. The drugs are grouped by pharmacologic classes.

5α-reductase inhibitors

Generic name Brand name
Dutasteride Avodart
Finasteride Proscar, Propecia

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Anticoagulants

Generic name Brand name
Warfarin* Coumadin
* Category D for women with mechanical heart valves

Antiprogestogens

Generic name Brand name
Mifepristone Korlym, Mifeprex

Anti-rheumatic

Generic name Brand name
Leflunomide Arava

Antivirals

Generic name Brand name
Ribavirin Copegus, Moderiba, Rebetol, Ribasphere, Virazole

Benzodiazepines

Generic name Brand name
Estazolam Prosom
Flurazepam Dalmane
Quazepam Doral
Temazepam Restoril
Triazolam Halcion
Benzodiazepines Pregnancy Category D:
Alprazolam (Xanax)
Chlordiazepoxide (Librium)
Clonazepam (Klonopin)
Clorazepate (Tranxene)
Diazepam (Valium)
Lorazepam (Ativan)
Oxazepam (Serax)

Endothelin Receptor Antagonists (ERA)

Generic name Brand name
Ambrisentan Letairis
Bosentan Tracleer
Macitentan Opsumit

Enzyme Inhibitors

Generic name Brand name
Miglustat Zavesca

Ergotamine Derivatives

Generic name Brand name
Ergotamine Ergomar
DihydroergotamineD D.H.E. 45

Hormone Replacement Therapy

ALL Hormone Replacement Therapy preparations are Pregnancy Category X.


Gonadotropin Preparations

Generic name Brand name
Menotropins Humegon, Menopur, Merional, Menogon, Metrodin, Repronex, Pergonal
Corifollitropinalfa Elonva
Choriogonadotropin alfa Ovidrel, Novarel, Pregnyl, chorionic gonadotropin
Follitropinalfa Gonal-f, Gonal-f RFF
Follitropin beta Follistim AQ
Urofollitropin Bravelle, Fertinorm

Gonadotropin-Releasing Hormone Agonist (Antigonadotropins)

Generic name Brand name
Buserelin Suprefact
Leuprorelin Lupron Depot
Cetrorelix Cetrotide
Nafarelin Synarel
Triptorelin Decapeptyl

Growth Hormone Releasing Factors

Generic name Brand name
Tesamorelin Egrifta

Immune System Suppressants

Generic name Brand name
Methotrexate Rheumatrex

Oral Contraceptives

ALL Oral Contraceptives (birth control pilles) are Pregnancy Category X medications.

Generic name
Desogestrel/Ethinylestradiol
Dienogest/Estradiol valerate
Drospirenone/Ethinylestradiol
Etynodiol/Ethinylestradiol
Levonorgestrel
Levonorgestrel/Ethinylestradiol
Mestranol/Norethindrone
Norelgestromin/Ethinylestradiol
Norethindrone acetate/Ethinylestradiol
Norethindrone acetate/ Ethinylestradiol/ Ferrous fumarate
Norethindrone/Ethinylestradiol
Norethindrone/ Ethinylestradiol/ Ferrous fumarate
Norgestimate/Ethinylestradiol
Norgestrel/Ethinylestradiol

Prostaglandin Analogues

Generic name Brand name
Misoprostol Cytotec

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Retinoids

Generic name Brand name
Acitretin Soriatan
Bexarotene Targretin
Etretinate Tegison
Isotretinoin Accutane
Tazarotene Tazorac
Pregnancy Category D:
Tretinoin (Retin-A)

Selective Eestrogen Receptor Modulators

Generic name Brand name
Clomiphene Clomid
Ospemifene Osphena
Raloxifene Evista

Statins (HMG-CoA reductase inhibitor)

Generic name Brand name
Atorvastatin Lipitor
Fluvastatin Lescol
Lovastatin Mevacor
Pitavastatin Livalo
Pravastatin Pravachol
Rosuvastatin Crestor
Simvastatin Zocor

Steroid Hormones

Generic name Brand name
Danazol Danocrine
Methyltestosterone Android
Oxandrolone Oxandrin
Testosterone Aveed, Delatestryl, Depo-Testosterone, Testopel, Xyosted

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Last updated: June 18, 2019
Published: June 18, 2019

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