List of Pregnancy Category X Medications
by eMedExpert staff
Pregnancy Category X drugs are contraindicated in women who are or may become pregnant. For medications assigned this category there are studies, adequate well-controlled or observational, in animals or pregnant women that have demonstrated positive evidence of fetal abnormalities.
The below list represents information on select medications that are classified as Pregnancy Category X (clearly teratogenic) medications. The listing is not inclusive, it may not cover all available medications on the world market. The drugs are grouped by pharmacologic classes.
5α-reductase inhibitors
| Generic name |
Brand name |
| Dutasteride |
Avodart |
| Finasteride |
Proscar, Propecia |
Anticoagulants
| Generic name |
Brand name |
| Warfarin* |
Coumadin |
| * Category D for women with mechanical heart valves |
Antiprogestogens
| Generic name |
Brand name |
| Mifepristone |
Korlym, Mifeprex |
Anti-rheumatic
| Generic name |
Brand name |
| Leflunomide |
Arava |
Antivirals
| Generic name |
Brand name |
| Ribavirin |
Copegus, Moderiba, Rebetol, Ribasphere, Virazole |
Benzodiazepines
| Generic name |
Brand name |
| Estazolam |
Prosom |
| Flurazepam |
Dalmane |
| Quazepam |
Doral |
| Temazepam |
Restoril |
| Triazolam |
Halcion |
Benzodiazepines Pregnancy Category D:
Alprazolam (Xanax)
Chlordiazepoxide (Librium)
Clonazepam (Klonopin)
Clorazepate (Tranxene)
Diazepam (Valium)
Lorazepam (Ativan)
Oxazepam (Serax) |
Endothelin Receptor Antagonists (ERA)
| Generic name |
Brand name |
| Ambrisentan |
Letairis |
| Bosentan |
Tracleer |
| Macitentan |
Opsumit |
Enzyme Inhibitors
| Generic name |
Brand name |
| Miglustat |
Zavesca |
Ergotamine Derivatives
| Generic name |
Brand name |
| Ergotamine |
Ergomar |
| DihydroergotamineD |
D.H.E. 45 |
Hormone Replacement Therapy
ALL Hormone Replacement Therapy preparations are Pregnancy Category X.
Gonadotropin Preparations
| Generic name |
Brand name |
| Menotropins |
Humegon, Menopur, Merional, Menogon, Metrodin, Repronex, Pergonal |
| Corifollitropinalfa |
Elonva |
| Choriogonadotropin alfa |
Ovidrel, Novarel, Pregnyl, chorionic gonadotropin |
| Follitropinalfa |
Gonal-f, Gonal-f RFF |
| Follitropin beta |
Follistim AQ |
| Urofollitropin |
Bravelle, Fertinorm |
Gonadotropin-Releasing Hormone Agonist (Antigonadotropins)
| Generic name |
Brand name |
| Buserelin |
Suprefact |
| Leuprorelin |
Lupron Depot |
| Cetrorelix |
Cetrotide |
| Nafarelin |
Synarel |
| Triptorelin |
Decapeptyl |
Growth Hormone Releasing Factors
| Generic name |
Brand name |
| Tesamorelin |
Egrifta |
Immune System Suppressants
| Generic name |
Brand name |
| Methotrexate |
Rheumatrex |
Oral Contraceptives
ALL Oral Contraceptives (birth control pilles) are Pregnancy Category X medications.
| Generic name |
| Desogestrel/Ethinylestradiol |
| Dienogest/Estradiol valerate |
| Drospirenone/Ethinylestradiol |
| Etynodiol/Ethinylestradiol |
| Levonorgestrel |
| Levonorgestrel/Ethinylestradiol |
| Mestranol/Norethindrone |
| Norelgestromin/Ethinylestradiol |
| Norethindrone acetate/Ethinylestradiol |
| Norethindrone acetate/ Ethinylestradiol/ Ferrous fumarate |
| Norethindrone/Ethinylestradiol |
| Norethindrone/ Ethinylestradiol/ Ferrous fumarate |
| Norgestimate/Ethinylestradiol |
| Norgestrel/Ethinylestradiol |
Prostaglandin Analogues
| Generic name |
Brand name |
| Misoprostol |
Cytotec |
Retinoids
| Generic name |
Brand name |
| Acitretin |
Soriatan |
| Bexarotene |
Targretin |
| Etretinate |
Tegison |
| Isotretinoin |
Accutane |
| Tazarotene |
Tazorac |
Pregnancy Category D:
Tretinoin (Retin-A) |
Selective Eestrogen Receptor Modulators
| Generic name |
Brand name |
| Clomiphene |
Clomid |
| Ospemifene |
Osphena |
| Raloxifene |
Evista |
Statins (HMG-CoA reductase inhibitor)
| Generic name |
Brand name |
| Atorvastatin |
Lipitor |
| Fluvastatin |
Lescol |
| Lovastatin |
Mevacor |
| Pitavastatin |
Livalo |
| Pravastatin |
Pravachol |
| Rosuvastatin |
Crestor |
| Simvastatin |
Zocor |
Steroid Hormones
| Generic name |
Brand name |
| Danazol |
Danocrine |
| Methyltestosterone |
Android |
| Oxandrolone |
Oxandrin |
| Testosterone |
Aveed, Delatestryl, Depo-Testosterone, Testopel, Xyosted |
Resources
Last updated: June 18, 2019
Published: June 18, 2019
