Increased Libido Side Effect

Increased libido means an increase in sexual desire.

At first glance it may seem that increased sexual desire is a positive effect or "pleasurable" side effect. However, an extremely high sex drive (known as hypersexuality) can interfere with lives and careers and have serious consequences:

  • Difficulties at work
  • Serious relationship problems.
  • Loss of interest in daily activities
  • Inadequate self-esteem

Medications that enhances dopamine neurotransmission are often associated with increased sexual desire6.

Drug Incidence
Anadrol
AndroGel Rare
Apokyn
Aripiprazole (Abilify®)13 < 1%
Bupropion (Wellbutrin®)8, 9 Bupropion has pro-sexual effects, including increased libido, intensity of orgasm, and arousal. May work as an antidote for drug-induced sexual dysfunction.
Cabergoline (Dostinex®)10 < 10%
Campral Infrequent
Celexa Infrequent
Clozapine < 1%
Clozaril < 1%
Delatestryl
Depo-Provera < 1%
Donepezil (Aricept®)4 1% to 10%
Effexor Infrequent
Exelon Infrequent
FazaClo < 1%
Gabitril Infrequent
Gengraf 1% to 3%
Haldol Decanoate
Klonopin Infrequent
Lamictal Rare
Librium
Lotensin < 1%
Lupron
Methylphenidate (Concerta®, Ritalin®)5 raises dopamine levels
Methyltestosterone (Testred®)
Moban
Namenda Infrequent
Neoral 1% to 3%
Norpramin
Parcopa®12
Paxil Rare
Permax Infrequent
Pramipexole (Mirapex®)14
Lansoprazole (Prevacid®, Prevpac®) < 1%
Prozac Infrequent
Rasagiline (Azilect®)7
Reminyl Infrequent
Requip Infrequent
Rilutek Infrequent
Risperidone (Risperdal®)11 Infrequent
Quetiapine (Seroquel®)3 Infrequent
Stalevo
Surmontil
Symbyax Rare
Tasmar Infrequent
Topamax Rare
Trazodone may increase sexual desire in both men and women1, 2
Trileptal
Xanax 1% to 10%
Zoloft Rare

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Aphrodisiac herbs

List of herbal supplements, that can stimulate sexual desire and performance, and increase pleasure15:

  • Tribulus terrestrins
  • Chlorophytum borivilianum
  • Withania somnifera
  • Panax ginseng
  • Eurycoma longifolia
  • Avena sativa
  • Ginko biloba
  • Myristica fragrans

References

  • 1. Sullivan G. Increased libido in three men treated with trazodone. J Clin Psychiatry. 1988 May;49(5):202-3. PubMed
  • 2. Gartrell N. Increased libido in women receiving trazodone. Am J Psychiatry. 1986 Jun;143(6):781-2. PubMed
  • 3. Menon A, Williams RH, Watson S. Increased libido associated with quetiapine. J Psychopharmacol. 2006 Jan;20(1):125-7. PubMed
  • 4. Segrec N, Zaman R, Pregelj P. Increased libido associated with donepezil treatment: a case report. Psychogeriatrics. 2016 Jan;16(1):70-2. PubMed
  • 5. Schmid Y1, Hysek CM1, Preller KH, et al. Effects of methylphenidate and MDMA on appraisal of erotic stimuli and intimate relationships. Eur Neuropsychopharmacol. 2015 Jan;25(1):17-25 PubMed
  • 6. Driver-Dunckley ED, Noble BN, Hentz JG, Evidente VG, Caviness JN, Parish J, Krahn L, Adler CH. Gambling and increased sexual desire with dopaminergic medications in restless legs syndrome. Clin Neuropharmacol. 2007 Sep-Oct;30(5):249-55. PubMed
  • 7. Reyes D, Kurako K, Galvez-Jimenez N. Rasagiline induced hypersexuality in Parkinson's disease. J Clin Neurosci. 2014 Mar;21(3):507-8. PubMed
  • 8. Labbate LA. Bupropion-SR-induced increased libido and spontaneous orgasm. Can J Psychiatry. 1998 Aug;43(6):644-5.
  • 9. Modell JG, May RS, Katholi CR. Effect of bupropion-SR on orgasmic dysfunction in nondepressed subjects. J Sex Marital Ther. 2000 Jul-Sep;26(3):231-40. PubMed
  • 10. Wittstock M, Benecke R, Dressler D. Cabergoline can increase penile erections and libido. Neurology. 2002 Mar 12;58(5):831. PubMed
  • 11. Xenitidis K, Campbell C, Davidson CK, Johnson T, Jansen K. Risperidone-induced hypersexuality. Br J Psychiatry. 2013 Sep;203(3):233 PubMed
  • 12. Both S, Everaerd W, Laan E, Gooren L. Effect of a single dose of levodopa on sexual response in men and women. Neuropsychopharmacology. 2005 Jan;30(1):173-83. PubMed
  • 13. Schlachetzki JC, Langosch JM. Aripiprazole induced hypersexuality in a 24-year-old female patient with schizoaffective disorder? J Clin Psychopharmacol. 2008 Oct;28(5):567-8.
  • 14. Moore TJ, Glenmullen J, Mattison DR.Reports of pathological gambling, hypersexuality, and compulsive shopping associated with dopamine receptor agonist drugs. JAMA Intern Med. 2014 Dec;174(12):1930-3. PubMed
  • 15. Malviya N, Jain S, Gupta VB, Vyas S. Recent studies on aphrodisiac herbs for the management of male sexual dysfunction. Acta Pol Pharm. 2011 Jan-Feb;68(1):3-8.

Published: September 01, 2016
Last updated: December 16, 2017

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