Decreased Libido Side Effect

Decreased libido means a reduction in sexual desire. Drug-induced loss of libido or decreased sex drive can be a serious problem that impacts both men and women and leads to poor treatment adherence.

Medications that often interfere with the sexual desire are antidepressants, antihypertensive medications8, antipsychotics 1, antiepileptic drugs3. Medications that affect prolactin, testosterone, DHEA, and serotonin receptors often affect libido.

List of medications that cause decreased sexual interest:

Drug Incidence
Abilify < 1%
Aciphex
Actiq < 1%
Adalat < 1%
Aldoclor
Aldoril
Ambien Rare
Amerge Rare
Anadrol-50
AndroGel < 3%
Aricept Infrequent
Asacol
Avinza < 5%
Avodart 0.3% to 3%
Axid
Blocadren 0.6%
Caduet < 2%
Calcijex
Campral Frequent
Casodex 2% to 5%
Cimetidine (Tagamet®)12
Citalopram (Celexa®)9 2%
Clozapine < 1%
Clozaril < 1%
Copaxone Infrequent
Coreg 0.1% to 1%
Corzide 0.1% to 0.5%
Cosopt
Cozaar < 1%
Progesterone gel Crinone 10%
Cymbalta 1% to 6%
Delatestryl
Depo-Provera 1% to 5%
Diovan > 0.2%
DynaCircR 0.5% to 1%
Effexor 2% to 9%
Eligard <3.3%
Estring
Exelon Infrequent
FazaClo < 1%
Finasteride (Propecia®)6 2.6% to 6.4%
Flomax 1% to 2%
Fluoxetine (Prozac®)7 1% to 11%
Gabapentin (Neurontin®)2
Gabitril Infrequent
Gengraf 1% to 3%
Glucotrol < 1%
Haloperidol (Haldol)
Hectorol
Hytrin 0.6%
Hyzaar
Imipramine (Tofranil)
Indapamide < 5%
Infergen 5%
Intron A < 5%
Inversine
Kadian < 3%
Kaletra < 2%
Klonopin 1%
Lamictal Rare
Lexapro 3% to 7%
Librium
Lipitor < 2%
Lofibra
Lotensin 0.3% to 1%
Lotrel
Lupron Depot 1.8% to 11%
MS Contin Less frequent
MSIR Less frequent
Mavik 0.3% to 1%
Meridia
Midamor < 1%
Mirapex 1%
Mirena > 5%
Moduretic
Nadolol 0.1% to 0.5%
Neoral 1% to 3%
Nilandron 11%
Norpramin
Norvir < 2%
Oral contraceptives decrease circulating free testosterone4, low testosterone levels in women are associated with suppressed libido
Oramorph SR Less frequent
Ovrette
OxyContin
Pacerone 1% to 3%
Paroxetine (Paxil®)7 7% to 12%
Pepcid Infrequent
Permax Infrequent
Phenelzine (Nardil)
Prevacid < 1%
Prevpac < 1%
Prinivil 0.4%
Prinzide 0.3% to 1%
ProSom Rare
Prochieve 10%
Protonix < 1%
Provigil > 1%
Requip Infrequent
Rescriptor
Reyataz < 3%
Rilutek Infrequent
Risperdal Consta Infrequent
Rocaltrol
Rythmol
Sandostatin < 1%
Seroquel Rare
Sertraline (Zoloft®)7 1% to 11%
Sonata Infrequent
Soriatane < 1%
Sporanox 0.2% to 1.2%
Statins11 statins cause low serum testosterone levels due to intracellular cholesterol depletion10, lower testosterone levels are associated with decreased male libido
Strattera > 5%
Sular < 1%
Surmontil
Symbyax 2% to 4%
Symmetrel 0.1% to 1%
Tambocor < 1%
Tarka
Tasmar Infrequent
Testred
Thalomid
Thioridazine (Mellaril)
Timolide < 1%
Timolol
Timoptic
Topamax 1% to 2%
Toprol-XL
Tricor
Trileptal,
Uniretic < 1%
VFEND < 1%
Vaseretic 0.5% to 2%
Vicoprofen < 1%
Xanax 6% to 14.4%
Zantac
Zoladex 61%
Zonegran Infrequent
Zyprexa Infrequent
Zyrtec < 2%

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References
  • 1. Stimmel GL. Gutierrez MA. Sexual dysfunction and psychotropic medications.CNS Spectr. 2006 Aug;11(8 Suppl 9):24-30. PubMed
  • 2. Kaufman KR, Struck PJ. Gabapentin-induced sexual dysfunction. Epilepsy Behav. 2011 Jul;21(3):324-6. PubMed
  • 3. Kaufman KR, Wong S, Sivaraaman K, Anim C, Delatte D. Epilepsy and AED-induced decreased libido - The unasked psychosocial comorbidity. Epilepsy Behav. 2015 Nov;52(Pt A):236-8. PubMed
  • 4. Lee M, Morgan M, Rapkin A. Clitoral and vulvar vestibular sensation in women taking 20 mcg ethinyl estradiol combined oral contraceptives: a preliminary study. J Sex Med. 2011 Jan;8(1):213-8 PubMed
  • 5. Shah MB, Hoffstetter S. Contraception and sexuality. Minerva Ginecol. 2010 Aug;62(4):331-47. PubMed
  • 6. Mondaini N, Gontero P, Giubilei G, Lombardi G, Cai T, Gavazzi A, Bartoletti R. Finasteride 5 mg and sexual side effects: how many of these are related to a nocebo phenomenon? J Sex Med. 2007 Nov;4(6):1708-12. PubMed
  • 7. Modell JG, Katholi CR, Modell JD, DePalma RL. Comparative sexual side effects of bupropion, fluoxetine, paroxetine, and sertraline. Clin Pharmacol Ther. 1997 Apr;61(4):476-87. PubMed
  • 8. Weiss RJ. Effects of antihypertensive agents on sexual function. Am Fam Physician. 1991 Dec;44(6):2075-82. PubMed
  • 9. Michael A, Herrod JJ. Citalopram-induced decreased libido. Br J Psychiatry. 1997 Jul;171:90.
  • 10. de Graaf L, Brouwers AH, Diemont WL. Is decreased libido associated with the use of HMG-CoA-reductase inhibitors? Br J Clin Pharmacol. 2004 Sep;58(3):326-8. PubMed
  • 11. Tuccori M1, Montagnani S, Mantarro S, et al. Neuropsychiatric adverse events associated with statins. CNS Drugs. 2014 Mar;28(3):249-72. PubMed
  • 12. Galbraith RA. Sexual side effects of drugs. Drug Ther (NY). 1991 Mar;21(3):38-40, 45. PubMed

Published: September 01, 2016
Last updated: September 01, 2016

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