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Trazodone, sold under the brand name Desyrel, is quite an old prescription antidepressant, that shares several properties of tricyclic antidepressants. It is one of the most widely prescribed medications for insomnia.

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• Active ingredient: Trazodone hydrochloride
• Brand names: Desyrel
• Drug class: Antidepressant, Serotonin Reuptake Inhibitor/Antagonist
• Legal status: RX only

Trazodone, classified as an atypical antidepressant, is indicated for the treatment of Major Depressive Disorder.

Trazodone off-label uses:

• Insomnia
• Panic disorder
• Anxiety disorder
• Migraine
• Alcohol withdrawal
• Erectile dysfunction
  

Depression:
The initial dose is 150 mg/day in 3 divided doses. The dose may be increased by 50 mg/day every 3 to 4 days. The maximum daily dose usually should not exceed 400 mg. Severely depressed patients may be given up to 600 mg/day in divided doses.

Insomnia:
Unlike benzodiazepine sleep aids, trazodone may help insomnia without next day grogginess and sedation.

Usually, the starting dose for insomnia is 25-50 mg at bedtime. The dose can be increased if necessary up to 100 mg. There is no need to increase the dose above 100 mg for this indication. It's sleep aid effect starts within 1-2 hours and usually lasts about 8 hours.

The sedative effects of trazodone are increased by other central nervous system depressants such as alcohol, sedatives, sleeping medications, and antidepressants.

When you recieve the prescription for antidepressant, you should know about possible risks.

In rare cases trazodone may cause priapism, a prolonged, painful erection. It occurs in 0.1-0.01% of men who take this medicine.

Taking trazodone in combination with other prescription medications, including MAO inhibitors, sibutramine (Meridia), SSRI antidepressants, and triptans, may lead to serotonin syndrome.