Metronidazole (Flagyl)
Description
- Active ingredient: Metronidazole
- Common brand names: Flagyl, Rozex, MetroGel
- Legal status: Prescription only
- Pregnancy Category: B
Metronidazole is a nitroimidazole antibiotic drug used in the treatment
of infections caused by susceptible organisms particularly anaerobic
bacteria and protozoa.
Metronidazole uses:
- Trichomoniasis: symptomatic, asymptomatic, asymptomatic consorts
- Amebiasis: acute intestinal amebiasis (amebic dysentery) and amebic
liver abscess
- Anaerobic Bacterial Infections
- Intra-abdominal infections, including peritonitis, intra-abdominal
abscess, and liver abscess
- Skin and skin structure infections
- Gynecologic infections, including endometritis, endomyometritis,
tubo-ovarian abscess, and postsurgical vaginal cuff infection
- Bacterial Septicemia
- Bone and joint infections, as adjunctive therapy
- Central Nervous System infections, including meningitis and
brain abscess
- Lower Respiratory Tract infections, including pneumonia, empyema,
and lung abscess
- Endocarditis
Dosage
- Acute amebic dysentery and amebic liver abscess
Adults 375 capsules: 750 mg 3 time daily for 5 to 10
days.
- Acute amebic dysentery
Adults 250 mg tablets: 750 mg 3 times daily for 5 to
10 days.
- Amebic liver abscess
Adults 250 mg tablets: 500 or 750 mg 3 times daily for
5 to 10 days.
- Amebiasis
Children: 375 mg, 250 mg tablets: 35 to 50 mg/kg per 24 h divided
into 3 daily doses for 10 days.
- Anaerobic Bacterial Infections
Adults: Usual dosage is 7.5 mg/kg (approximately 500
mg for a 70 kg adult) every 6 h (max, 4 g per 24 h) for 7 to 10 days;
however, infections of the bone, joint, lower respiratory tract, and
endocardium may require longer treatment.
- Bacterial Vaginosis
Adults: 750 mg (ER) daily for 7 consecutive days. Vaginal
1 applicator-full (approximately 37.5 mg metronidazole) intravaginally
once or twice daily for 5days; for daily dosing, administer at bedtime
- Inflammatory Papules and Pustules of Rosacea
Adults: Topical: Apply thin layer once daily (1% cream)
or twice daily to entire affected areas after washing. Use morning
and evening or as directed by health care provider. Avoid application
close to eyes.
- Trichomoniasis
Adults:
375 capsules: Women: 375 mg twice daily for 7 consecutive
days. When a repeat course is required, a lapse of 4 to 6 wk between
courses is recommended.
250 mg tablets: 250 mg 3 times daily for 7 consecutive days.
One-day treatment 2 g as a single dose or in 2 divided doses of 1
g each given on the same day.
Children: 5 mg/kg/dose 3 times daily for 7 days.
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