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Metronidazole (Flagyl)

Description
  • Active ingredient: Metronidazole
  • Common brand names: Flagyl, Rozex, MetroGel
  • Legal status: Prescription only
  • Pregnancy Category: B

Metronidazole is a nitroimidazole antibiotic drug used in the treatment of infections caused by susceptible organisms particularly anaerobic bacteria and protozoa.

Metronidazole uses:

  • Trichomoniasis: symptomatic, asymptomatic, asymptomatic consorts
  • Amebiasis: acute intestinal amebiasis (amebic dysentery) and amebic liver abscess
  • Anaerobic Bacterial Infections
    • Intra-abdominal infections, including peritonitis, intra-abdominal abscess, and liver abscess
    • Skin and skin structure infections
    • Gynecologic infections, including endometritis, endomyometritis, tubo-ovarian abscess, and postsurgical vaginal cuff infection
    • Bacterial Septicemia
    • Bone and joint infections, as adjunctive therapy
    • Central Nervous System infections, including meningitis and brain abscess
    • Lower Respiratory Tract infections, including pneumonia, empyema, and lung abscess
    • Endocarditis
Dosage
  • Acute amebic dysentery and amebic liver abscess
    Adults 375 capsules: 750 mg 3 time daily for 5 to 10 days.
  • Acute amebic dysentery
    Adults 250 mg tablets: 750 mg 3 times daily for 5 to 10 days.
  • Amebic liver abscess
    Adults 250 mg tablets: 500 or 750 mg 3 times daily for 5 to 10 days.
  • Amebiasis
    Children: 375 mg, 250 mg tablets: 35 to 50 mg/kg per 24 h divided into 3 daily doses for 10 days.
  • Anaerobic Bacterial Infections
    Adults: Usual dosage is 7.5 mg/kg (approximately 500 mg for a 70 kg adult) every 6 h (max, 4 g per 24 h) for 7 to 10 days; however, infections of the bone, joint, lower respiratory tract, and endocardium may require longer treatment.
  • Bacterial Vaginosis
    Adults: 750 mg (ER) daily for 7 consecutive days. Vaginal 1 applicator-full (approximately 37.5 mg metronidazole) intravaginally once or twice daily for 5days; for daily dosing, administer at bedtime
  • Inflammatory Papules and Pustules of Rosacea
    Adults: Topical: Apply thin layer once daily (1% cream) or twice daily to entire affected areas after washing. Use morning and evening or as directed by health care provider. Avoid application close to eyes.
  • Trichomoniasis
    Adults:
    375 capsules: Women: 375 mg twice daily for 7 consecutive days. When a repeat course is required, a lapse of 4 to 6 wk between courses is recommended.
    250 mg tablets: 250 mg 3 times daily for 7 consecutive days.
    One-day treatment 2 g as a single dose or in 2 divided doses of 1 g each given on the same day.
    Children: 5 mg/kg/dose 3 times daily for 7 days.