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Neurontin® (Gabapentin)Gabapentin (brand Neurontin®, Pfizer) was initially developed as an anti-epileptic prescription. Today it is widely prescribed for the management of various types of pain, including postherpetic neuralgia, nerve pain, headaches, fibromyalgia, restless leg syndrome. It is also used to reduce anxiety and agitation in persons with bipolar disorder. Price
Neurontin® is rather expensive. Even its generic version is not a very cheap solution. Although the cost may be an issue, for persons unable to tolerate tricyclic antidepressants or other anticonvulsants, gabapentin is a reasonable alternative1. How to use
Officially, Gabapentin is indicated as adjunct to control partial seizures with and without secondary generalization in adults and children (3 years of age and older). It is also approved for the management of postherpetic neuralgia (nerve pain after shingles). Scientific data shows that Gabapentin is an effective prescription solution for various health conditions with no serious side effects. Despite the drug was invented for its use in epilepsy and seizures, it is prescribed for a number of unapproved uses, including interstitial cystitis, bipolar disease, attention deficit disorder, restless legs syndrome, alcohol withdrawal, premenstrual syndrome. Gabapentin has been found to reduce various types of itches without rash. A similar mechanism of pain and itch sensations may explain the therapeutic benefit of the drug. The obvious inconvenience of gabapentin is three times-a-day dosing needed in most ailments. Important advantage over older anticonvulsants is a lack of significant interactions with prescription and non-prescription medications. It is particularly beneficial for elderly people. Precautions & Contraindications Discontinuance of gabapentin should be done gradually over a minimum of 1 week. Abrupt discontinuation may cause symptoms of anxiety, irritability, agitation, confusion, tachycardia, and seizures. Gabapentin can produce drowsiness, dizziness, and may impair the ability to perform hazardous activities requiring mental alertness or physical coordination. Don't engage in any activity that requires alertness until you are sure you can perform such activities safely. Side effects Somnolence, dizziness, drowsiness, ataxia, fatigue, diplopia, nystagmus, peripheral edema, tremor. Dosage Epilepsy: The usual dosage for seizures is 900 mg to 1.800 mg per day divided 3 times daily. The interval between doses should not exceed 12 hours. Postherpetic neuralgia: The usual dosage is 1.800 mg daily in 3 divided doses. Gabapentin is often initiated at a dose of 300 mg daily and is increased gradually over next several days until effectiveness is reached. Additional benefit of taking more than 1800 mg a day was not demonstrated, although daily doses up to 3.600 mg have been well tolerated. References
Last updated: January 27, 2012 |