Nabumetone (Relafen) versus ...
Nabumetone produces significantly less deterioration of gastric mucosa and has a significantly lower ulcerogenic potential than naproxen2. Also, nabumetone is better tolerated.
Nabumetone has less effect on platelet aggregation than naproxen in patients with rheumatoid arthritis5.
Nabumetone is of equal efficacy to naproxen in the treatment of active rheumatoid arthritis1.
A 3-month, randomized, double-blind, multicenter, parallel-group study6 compared the tolerability and efficacy of nabumetone and naproxen in the treatment of rheumatoid arthritis (RA). Nabumetone 2000 mg per day was as effective as naproxen 1000 mg per day in relieving the signs and symptoms of RA. In this study nabumetone was associated with a higher incidence of diarrhea.
Naproxen may be superior to nabumetone in the treatment of active osteoarthritis (OA) of the knee.
The efficacy and safety of Naprelan (naproxen sodium) and nabumetone were compared in a multicenter, randomized, placebo-controlled, double-masked, 4-week study of adults with active OA of the knee11. The overall distribution of scores in all three primary efficacy assessments (investigator's global assessment of OA, patient's global assessment of OA, and walking pain) at week 2 and at the last visit was significantly better for the Naprelan group compared with both the nabumetone and placebo groups. The mean improvement from baseline was also significant for Naprelan compared with the nabumetone and placebo groups for all three assessments at week 2 and for investigator's global assessment of OA and walking pain at the last visit. At week 2, significant differences favoring Naprelan versus nabumetone and placebo were measured in overall distribution of scores for joint tenderness and nighttime pain. At the last visit, nighttime pain scores were still significantly better for patients receiving Naprelan versus nabumetone and placebo.
Nabumetone has significantly fewer gastrointestinal tract side effects than diclofenac9.
Nabumetone is as effective as diclofenac sodium in the management of rheumatoid arthritis (RA) symptoms.
A randomized, open-label, controlled, multicenter, 12-week study3 compared the efficacy and safety of nabumetone and diclofenac sodium in the treatment of RA.
The total efficacy rate of nabumetone was as high as that of diclofenac sodium (92.31% vs 88.52%). The mean score of endoscopic gastrointestinal lesions in the nabumetone group was significantly lower in the end of the treatment than those of their base line scoring, and there was no significant change with regard to the diclofenac sodium group. The incidence of ulcer disease associated with nabumetone was 0% and 2.70% with diclofenac sodium.
Nabumetone is similar in efficacy and superior in tolerability to diclofenac SR in patients with osteoarthritis4.
Etodolac is at least as effective as nabumetone and is equally well tolerated in the treatment of active osteoarthritis of the knee7. Etodolac may have an earlier onset of action and a relatively greater efficacy than nabumetone.
Both nabumetone and meloxicam are cyclo-oxygenase-2 (COX-2) preferential nonsteroidal anti-inflammatory drugs (NSAIDs).
Nabumetone inhibits thromboxane production much more than meloxicam, indicating less COX-2 selectivity of nabumetone. However, both nabumetone and meloxicam cause only minor impairment in platelet function and the difference between them is not significant8.
An 8-week, multicenter, randomized, double-blind, double-dummy study10 compared the efficacy and tolerability of SAMe and nabumetone in Korean patients with knee osteoarthritis (OA). This study found no significant differences in pain relief or tolerability between treatment with SAMe or nabumetone.
Published: November 01, 2013