Minocycline (Minocin) versus Other
Minocycline vs. Tetracycline
Minocycline may be effective for patients with tetracycline-recalcitrant acne vulgaris. It has much greater antibacterial activity against both Staphylococci and Propionibacterium acnes and produces less resistance than tetracycline1-2.
Minocycline and tetracycline are similarly effective in the treatment of non-gonococcal urethritis6.
In comparative study5 61 of 77 (79%) men treated with tetracycline and 53 of 68 (78%) men treated with minocycline were free from urethritis one to two weeks after completing treatment. Both agents were clinically effective against C trachomatis, but activity against U urealyticum was less consistent. Side effects were noted in 14 (18%) men treated with tetracycline and eight (12%) men treated with minocycline; they were predominantly gastrointestinal.
Minocycline vs. Cephalexin
Minocycline appears to be more effective than cephalexin in the treatment of acute or chronic prostatitis.
In the multicenter study7 42 men received minocycline (200-mg initially followed by 100 mg twice daily) and 44 cephalexin (500 mg four times daily) for four weeks. Evaluable data were available for 20 minocycline-treated patients and for 24 cephalexin-treated patients. Improvement in symptoms was seen in 65% of the patients who received minocycline and in 46% of those given cephalexin. Bacteriologic cure without relapse or reinfection occurred in 45% of the minocycline-treated men and in 21% of the cephalexin-treated men. Serious adverse clinical experiences were not encountered in either group.
Minocycline vs. Lymecycline (Tetralysal)
There is some evidence that minocycline is more effective than lymecycline in the treatment of inflammatory acne.
A trial8 involving patients with moderate to moderately severe acne vulgaris, found that minocycline (100 mg daily for 4 weeks followed by 50 mg daily for 8 weeks) was superior to lymecycline (300 mg daily for 12 weeks) in the reduction of the number of lesions.
However, in clinical trials, the proportion of people who perceived their appearance to have improved was greater with lymecycline9. For example, these numbers were 65% (44 out of 68) with minocycline and 86% (57 out of 66) with lymecycline. Also, lymecycline seems to be somewhat better in improving non-inflammatory lesions (median percents were 47% for minocycline and 54% for lymecycline).
Published: March 31, 2008