Citalopram (Celexa) versus ...
- Citalopram vs Reboxetine
- Citalopram vs Fluoxetine
- Citalopram vs Escitalopram
- Citalopram vs Nortriptyline
- Citalopram vs Amitriptyline
- Citalopram vs Mirtazapine
Reboxetine may be more effective than citalopram in treating depression with high levels of fatigue 2.
|Results of double-blind study comparing reboxetine with citalopram in major depressive disorder 1.||Citalopram||Reboxetine|
|Regimen||20-40 mg per day during 24 weeks||8-10 mg per day during 24 weeks|
|Reduction of HAM-D scores||
greater reduction of the HAM-D scores
|Most common side effect||sexual dysfunction||dry mouth|
|Anorgasmia rate in sexually active women at week 24||
|Dropout, number of patients||
|Results of randomized double-blind comparison of citalopram versus reboxetine in outpatients with somatoform pain disorder. 3.||Citalopram||Reboxetine|
|Regimen||40 mg/day (N=17 patients)||8 mg/day (N=18 patients)|
|Present Pain Intensity (PPI) scores at baseline and after treatment||
3.5 vs. 2.8
3.7 vs. 3.1
|Total Pain Rating Index (tPRI) scores at baseline and after treatment||
41.9 vs. 30.0
35.2 vs. 31.5
|Results of single-blind, cross-over, flexible-dose pilot study of reboxetine and citalopram in panic disorder4.||Citalopram||Reboxetine|
|Response rate at week 18||9 of 11 patients (82%)||7 of 13 patients (54%)|
|1 non-responder to citalopram responded to reboxetine.
3 non-responders to reboxetine responded to citalopram.
|Results of randomized single-blind study of citalopram versus nortriptyline in late-life depression 5.||Citalopram||Nortriptyline|
|Number of drop-outs||
|Autonomic side-effects||citalopram is better tolerated||
significantly higher, particularly in endogenous or psychotic patients
|Results of comparison of citalopram versus amitriptyline in the treatment of major depression 6.||Citalopram||Amitriptyline|
|Percentage reduction on the Hamilton Depression Rating Scale||
|Percentage reduction at the end of the study on the CGI-Improvement Scale||
|Adverse effects rate||
|Results of comparison of the tolerability and efficacy of citalopram and amitriptyline in elderly depressed patients 8.||Citalopram||Amitriptyline|
|Regimen||20 or 40 mg/day||50 or 100 mg/day|
|Time-related declines in severity of depression||
by 8 weeks slightly more than 50% of the patients in each antidepressant group experienced marked recovery
|Dry mouth, rate||7%||34%|
|Somnolence, constipation, fatigue||more frequently|
Comorbidity of depression, migraine, and tension-type headache
Amitriptyline and citalopram are equally efficient in relieving depressive symptoms. However, amitriptyline appears to be more efficacious than citalopram in reducing migraine and tension-type headache attacks11.
Combined therapy with amitriptyline and citalopram may be particularly beneficial for individuals with tension-type headache, migraine and comorbid depression that do not respond to monotherapy.
Chronic tension-type headache
Amitriptyline can significantly reduce the duration of headache, headache frequency, and intake of analgesics, whereas citalopram has no significant useful effect 12.
Mirtazapine and citalopram are equally effective in reducing symptoms of depression and anxiety. However, mirtazapine was significantly more effective than citalopram after 2 weeks of treatment on the MADRS, HAM-A and CGI Severity of illness and Quality of life scales 10. Mirtazapine may provide faster improvement of sleep, quality of sleep and improved alertness following awakening.
|Results of a double-blind, randomized study of mirtazapine versus citalopram in patients with major depressive disorder10.||Citalopram||Mirtazapine|
|Mean MADRS scores after 8 weeks||9.1||8.9|
|Percentage of patients prematurely terminated the study||3%||3.6%|
|Most frequent side effects||sweating and nausea||increased appetite and complaints of weight increase|
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Published: March 31, 2008
Last updated: August 14, 2014