Cephalexin (Keflex) versus ...
Cephalexin vs. Cefadroxil
- Pyodermas. Once-daily cefadroxil offers greater bacteriologic
eradication and a better overall effective response than twice-daily
cephalexin for the treatment of pyodermas caused by gram-positive
pathogens in children and adolescents.
- Streptococcal tonsillopharyngitis. Cephalexin twice daily
or three times daily and cefadroxil once daily appear equivalent
in bacteriologic and clinical cure of streptococcal tonsillopharyngitis
- Side effects and tolerability: Cefadroxil may be given
at less frequent intervals than cephalexin.
Cephalexin vs. Cefdinir
Skin and skin-structure infections. Cefdinir is as effective
as cephalexin in the treatment of mild-to-moderate skin and skin-structure
infections. In the study significantly more isolated pathogens were
resistant to cephalexin than to cefdinir 2
- Side effects and tolerability: Cefdinir is associated
with the higher rate of adverse reactions than cephalexin 2.
Cephalexin vs. Cephradine
- Efficacy: Cephradine was compared to cephalexin a
randomized, double-blind study for the treatment of bacterial infections
in children. Both proved to be equally safe and effective
for use paediatric practice 1.
Cephalexin vs. Penicillin
- Group A streptococcal throat infections. Cephalexin is a
more effective than penicillin in the treatment of group A beta-hemolytic
streptococcal throat infection in children 7.
- Impetigo. Cephalexin is much more effective treatment, than
penicillin V for impetigo 8.
Cephalexin vs. Ofloxacin
- Skin, skin structure, and soft-tissue infections. Both ofloxacin
and cephalexin are safe and effective in the treatment of skin and
soft-tissue infections 5.
Cephalexin vs. Azithromycin
- Skin and skin structure infections. A five-day, once-daily
regimen of azithromycin is as effective as a ten-day, twice-daily
regimen of cephalexin in the treatment of skin and skin structure
Cephalexin vs. Minocycline
- Bacterial prostatitis. In multicenter study more patients
in the minocycline-treated group had both clinical and bacteriologic
cures (35%) than did those in the cephalexin-treated group (21%) 9.
- 1. Mouallem R. Comparative efficacy and safety of cephradine and
cephalexin in children. J Int Med Res. 1976;4(4):265-71. PubMed
- 2. Tack KJ, Littlejohn TW, Mailloux G, Wolf MM, Keyserling
CH. Cefdinir versus cephalexin for the treatment of skin and skin-structure
infections. Clin Ther.
1998 Mar-Apr;20(2):244-56 PubMed
- 4. Curtin CD, Casey JR, Murray PC, Cleary CT, Hoeger WJ,
Marsocci SM, Murphy ML, Francis AB, Pichichero ME. Efficacy
of cephalexin two vs. three times daily vs. cefadroxil once daily
for streptococcal tonsillopharyngitis. Clin Pediatr (Phila). 2003
- 5. Powers RD, Schwartz R, Snow RM, Yarbrough DR III. Ofloxacin
versus cephalexin in the treatment of skin, skin structure, and soft-tissue
infections in adults. Clin Ther. 1991 Nov-Dec;13(6):727-36. PubMed
- 6. Kiani R. Comparison of azithromycin
and cephalexin in the treatment of skin and skin structure infections.
Eur J Clin Microbiol Infect Dis. 1991 Oct;10(10):880-4. PubMed
- 7. Disney FA, Dillon H, Blumer JL, Dudding BA, McLinn
SE, Nelson DB, Selbst SM. Am J Dis
Child. 1992 Nov;146(11):1324-7. PubMed
- 8. Demidovich CW, Wittler RR, Ruff ME, Bass JW, Browning
WC. Impetigo. Current etiology and comparison of penicillin
and cephalexin therapies. Am J Dis Child. 1990 Dec;144(12):1313-5.
- 9. Paulson DF, Zinner NR, Resnick MI, Childs SJ, Love T, Madsen PO. Treatment of bacterial prostatitis. Comparison of
cephalexin and minocycline. Urology. 1986 Apr;27(4):379-87. PubMed
Published: March 31, 2008
Last updated: May 29, 2011