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Azithromycin (Zithromax) versus ...

Azithromycin (Zithromax) vs. Minocycline

Acne

Azithromycin is at least as effective as minocycline in the treatment of facial comedonic and papulopustular acne1.

Results of open comparison of azithromycin vs minocycline in the treatment of acne comedonica and papulo-pustulosa1 Azithromycin Minocycline
Regimen 500 mg per day for 4 days in 4 cycles every 10 days 100 mg daily for 6 weeks
Satisfactory clinical response rate 75.8% 70.5%
Mild side effects rate 10.3% 11.7%

Azithromycin (Zithromax) vs. Cefadroxil (Duricef)

Skin infections

Azithromycin may be somewhat more effective and better tolerated than cefadroxil for treating uncomplicated skin and skin structure infections2.

Results of multicenter, investigator-blind trial of patients with uncomplicated skin and skin structure infections 2
Azithromycin
Cefadroxil
Regimen 500 mg on day 1, followed by 250 mg once a day on days 2 to 5 500 mg twice a day for 10 days)
Clinical success rates between days 10 and 13 97% (111 of 114) 96% (101 of 105)
Bacteriologic eradication for Staphylococcus aureus (between days 10 and 13) 94% (64 of 68) 86% (60 of 70)
Bacteriologic eradication for Streptococcus pyogenes (between days 10 and 13) 80% (4 of 5) 100% (6 of 6)
Clinical success rates between days 28 and 32 100% (82 of 82) 90% (75 of 83)
Bacteriologic eradication for Staphylococcus aureus (between days 28 and 32) 100% (59 of 59) 89% (56 of 63)
Bacteriologic eradication for Streptococcus pyogenes (between days 28 and 32) 100% (4of 4) 83% (5 of 6)
Number of ptients who discontinued therapy because of side effects none of the 152 patients 5 of 139 patients (4%)
Incidence of treatment-related adverse events
similar

Azithromycin (Zithromax) vs. Cefdinir (Omnicef)

Otitis media

Cefdinir and azithromycin have comparable effectiveness in the treatment of acute otitis media3.

Results of multicenter, prospective, investigator-blinded study of children (between the ages of 6 months and 6 years) with a clinical diagnosis of AOM 3
Azithromycin
Cefdinir
Regimen 10 mg/kg once daily on day 1 and 5 mg/kg once daily on days 2 through 5 7 mg/kg q12h for 5 days
Clinical cure rates 85% (149 patients of 176) 87% (151 patients of 174)
Clinical cure rates at the follow-up visit 86% 76%
Parents' satisfaction with regard to ease of use, taste, compliance, health care resource utilization, and missed days of work and day-care
similar

Further reading

References
  • 1. Gruber F, Grubisic'-Greblo H, Kastelan M, Brajac I, Lenkovic' M, Zamolo G. Azithromycin compared with minocycline in the treatment of acne comedonica and papulo-pustulosa. J Chemother. 1998 Dec;10(6):469-73. PubMed
  • 2. Jennings MB, McCarty JM, Scheffler NM, Puopolo AD, Rothermel CD. Comparison of azithromycin and cefadroxil for the treatment of uncomplicated skin and skin structure infections. Cutis. 2003 Sep;72(3):240-4.
  • 3. Block SL, Cifaldi M, Gu Y, Paris MM. A comparison of 5 days of therapy with cefdinir or azithromycin in children with acute otitis media. Clin Ther. 2005 Jun;27(6):786-94. PubMed

Published: March 31, 2008
Last updated: January 12, 2014

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