Azithromycin (Zithromax) versus ...
- Azithromycin vs Clarithromycin
- Azithromycin vs Doxycycline
- Azithromycin vs Amoxicillin
- Azithromycin vs Amoxicillin/Clavulanate
- Azithromycin vs Penicillin
- Azithromycin vs Minocycline
- Azithromycin vs Cefadroxil
- Azithromycin vs Cefdinir
Azithromycin is at least as effective as minocycline in the treatment of facial comedonic and papulopustular acne1.
|Results of open comparison of azithromycin vs minocycline in the treatment of acne comedonica and papulo-pustulosa1||Azithromycin||Minocycline|
|Regimen||500 mg per day for 4 days in 4 cycles every 10 days||100 mg daily for 6 weeks|
|Satisfactory clinical response rate||75.8%||70.5%|
|Mild side effects rate||10.3%||11.7%|
Azithromycin may be somewhat more effective and better tolerated than cefadroxil for treating uncomplicated skin and skin structure infections2.
|Results of multicenter, investigator-blind trial of patients with uncomplicated skin and skin structure infections 2||Azithromycin||Cefadroxil|
|Regimen||500 mg on day 1, followed by 250 mg once a day on days 2 to 5||500 mg twice a day for 10 days)|
|Clinical success rates between days 10 and 13||97% (111 of 114)||96% (101 of 105)|
|Bacteriologic eradication for Staphylococcus aureus (between days 10 and 13)||94% (64 of 68)||86% (60 of 70)|
|Bacteriologic eradication for Streptococcus pyogenes (between days 10 and 13)||80% (4 of 5)||100% (6 of 6)|
|Clinical success rates between days 28 and 32||100% (82 of 82)||90% (75 of 83)|
|Bacteriologic eradication for Staphylococcus aureus (between days 28 and 32)||100% (59 of 59)||89% (56 of 63)|
|Bacteriologic eradication for Streptococcus pyogenes (between days 28 and 32)||100% (4of 4)||83% (5 of 6)|
|Number of ptients who discontinued therapy because of side effects||none of the 152 patients||5 of 139 patients (4%)|
|Incidence of treatment-related adverse events||
Cefdinir and azithromycin have comparable effectiveness in the treatment of acute otitis media3.
|Results of multicenter, prospective, investigator-blinded study of children (between the ages of 6 months and 6 years) with a clinical diagnosis of AOM 3||Azithromycin||Cefdinir|
|Regimen||10 mg/kg once daily on day 1 and 5 mg/kg once daily on days 2 through 5||7 mg/kg q12h for 5 days|
|Clinical cure rates||85% (149 patients of 176)||87% (151 patients of 174)|
|Clinical cure rates at the follow-up visit||86%||76%|
|Parents' satisfaction with regard to ease of use, taste, compliance, health care resource utilization, and missed days of work and day-care||
- 1. Gruber F, Grubisic'-Greblo H, Kastelan M, Brajac I, Lenkovic' M, Zamolo G. Azithromycin compared with minocycline in the treatment of acne comedonica and papulo-pustulosa. J Chemother. 1998 Dec;10(6):469-73. PubMed
- 2. Jennings MB, McCarty JM, Scheffler NM, Puopolo AD, Rothermel CD. Comparison of azithromycin and cefadroxil for the treatment of uncomplicated skin and skin structure infections. Cutis. 2003 Sep;72(3):240-4.
- 3. Block SL, Cifaldi M, Gu Y, Paris MM. A comparison of 5 days of therapy with cefdinir or azithromycin in children with acute otitis media. Clin Ther. 2005 Jun;27(6):786-94. PubMed
Published: March 31, 2008
Last updated: January 12, 2014